Doxycycline is indicated for the treatment of the following infections:
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Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae.
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Respiratory tract infections caused by Mycoplasma pneumoniae.
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Lymphogranuloma venereum caused by Chlamydia trachomatis.
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Psittacosis (ornithosis) caused by Chlamydophila psittaci.
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Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence.
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Inclusion conjunctivitis caused by Chlamydia trachomatis.
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Uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis.
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Nongonococcal urethritis caused by Ureaplasma urealyticum.
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Relapsing fever due to Borrelia recurrentis.
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms:
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Chancroid caused by Haemophilus ducreyi.
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Plague due to Yersinia pestis.
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Tularemia due to Francisella tularensis.
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Cholera caused by Vibrio cholerae.
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Campylobacter fetus infections caused by Campylobacter fetus.
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Brucellosis due to Brucella species (in conjunction with streptomycin).
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Bartonellosis due to Bartonella bacilliformis.
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Granuloma inguinale caused by Klebsiella granulomatis.
Doxycycline is indicated for treatment of infections caused by the following gram-negative bacteria, when bacteriologic testing indicates appropriate susceptibility to the drug:
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Escherichia coli.
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Enterobacter aerogenes.
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Shigella species.
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Acinetobacter species.
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Respiratory tract infections caused by Haemophilus influenzae.
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Respiratory tract and urinary tract infections caused by Klebsiella species.
Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
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Upper respiratory infections caused by Streptococcus pneumoniae.
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Anthrax due to Bacillus anthracis, including inhalational anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis.
When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections:
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Uncomplicated gonorrhea caused by Neisseria gonorrhoeae.
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Syphilis caused by Treponema pallidum.
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Yaws caused by Treponema pallidum subspecies pertenue.
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Listeriosis due to Listeria monocytogenes.
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Vincent’s infection caused by Fusobacterium fusiforme.
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Actinomycosis caused by Actinomyces israelii.
• Infections caused by Clostridium species. In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
In severe acne, doxycycline may be useful adjunctive therapy.
Doxycycline is indicated for the prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains.
