Intramuscular penicillin G benzathine is indicated in the treatment of infections due to
penicillin-G-sensitive microorganisms that are susceptible to the low and very prolonged serum
levels common to this particular dosage form. Therapy should be guided by bacteriological
studies (including sensitivity tests) and by clinical response.
The following infections will usually respond to adequate dosage of intramuscular penicillin G
benzathine:
Mild-to-moderate infections of the upper-respiratory tract due to susceptible streptococci.
Venereal infections—Syphilis, yaws, bejel, and pinta.
Medical Conditions in which Penicillin G Benzathine Therapy is indicated as Prophylaxis:
Rheumatic fever and/or chorea—Prophylaxis with penicillin G benzathine has proven effective in
preventing recurrence of these conditions. It has also been used as follow-up prophylactic therapy
for rheumatic heart disease and acute glomerulonephritis.
