Methotrexate Injection is a folate analog metabolic inhibitor indicated for:
• The following neoplastic diseases for the:
o Treatment of adult and pediatric patients with acute lymphoblastic
leukemia as part of a combination chemotherapy regimen
o Prophylaxis and treatment of adult and pediatric patients with
meningeal leukemia
o Treatment of adult and pediatric patients with non-Hodgkin
lymphoma
o Treatment of adult and pediatric patients with osteosarcoma as part of
a combination chemotherapy regimen
o Treatment of adults with breast cancer as part of a combination
chemotherapy regimen
o Treatment of adults with squamous cell carcinoma of the head and
neck as single-agent
o Treatment of adults with gestational trophoblastic neoplasia as part of
a combination chemotherapy regimen
• Treatment of adults with rheumatoid arthritis (RA).
• Treatment of pediatric patients with polyarticular juvenile idiopathic
arthritis (pJIA).
• Treatment of adults with severe psoriasis.
